Nuance Pharma

We Are A Specialty Care
Biopharma Company

Committed To Bringing Transformational Therapies
To Patients In China And Asia

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Fit For Purpose

We Transcend Clinical Application Insights That Drive Our
Clinical Development Strategy Through A Dual Wheel Model
Of Our Integrated Commercial Platform And Late Stage
Clinical Pipeline

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Specialty Care
Boutique

We Focus On Developing First-in-Class Innovative Pipeline
To Address Unmet Medical Needs In Respiratory For The
Vast Patient Community In Asia
Asia Pac Vision

We Are Passionate About Exploring APAC Business Opportunities
And Have Substantive Progress In Our Asian Expansion Strategy
Bringing Therapies That Are More Accessible To People In China And Asia

Our Area Of Focus

We Have Developed A Differentiated Matrix Of Commercial Products And Innovative Pipeline Across Respiratory, Emergency Care, Iron Deficiency Anemia, Pain Management

Highlights

Founded by Mark Lotter in 2014, Nuance deploys the Dual Wheel model that develops a leading innovative pipeline, while maintaining a self-sustainable commercial operation in both China and Asia

5^PRODUCTS

COMMERCIAL
4^PIPELINE

LATE STAGE CLINICAL
300⁺

EMPLOYEES WORLDWIDE

Our Transformative Journey

2025

Approval of Ohtuvayre™ (ensifentrine) in Macau SAR, China

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2024

US FDA approved Ohtuvayre (ensifentrine) for the maintenance treatment of COPD

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2023

Completed dosing of First Patient in Ensifentrine China phase 3 trial for COPD

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2022

Launched nasal spray Bentrio™ in Hong Kong
Licensed in allergy alleviation / virus prevention nasal spray Bentrio™ from Altamira Therapeutics

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2021

Licensed in First-in-Class COPD dual MOA PDE 3&4 inhibitor Ensifentrine from Verona Pharma
Licensed in neonatal RDS drug / device combo Aerofact™ from Aerogen Pharma
Acquired Sino Health with access to 3 emergency care products and a GSP license in Zhuhai

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2020

Licensed in post-operative pain product Ketorolac (NTM-001) from Neumentum
Raised US$ 181 million Series D equity funding

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2019

Acquired NIFEREX Iron Polysaccharide Complex Capsules

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2018

Established partnership with Aerogen Pharma on nebulizer device
Accumulatively raised US$ 80 million equity funding

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2014

Mr. Mark Lotter founded Nuance Pharma in Shanghai

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